Research Articles

Effects of Invasive Plant Leaf Litter on a Lake Ecosystem

Published Jun 15, 2017

Abstract Invasive plants are introduced into foreign ecosystems and proliferate easily. These plants often have no natural consumers in their new environment, allowing them to outcompete neighboring native plants, causing a plethora of detriments. This research aimed to help solve a rarely investigated aspect of this problem: the effect of invasive plant leaf litter on… Read more

What Drives Us? Chasing Reward in a Dopaminergic Society

Published Jun 15, 2017

Abstract An individual’s level of motivation is often heavily attributed as a personality trait-it’s a quality we group with self- control to embody the ideal achiever capable of success in our society. However, seemingly discrete identification of personality traits understates a major component of the motivational driving force: the dopamine mesolimbic reward system, commonly known… Read more

Direct Imaging of Exoplanets with Project 1640

Published Jun 15, 2017

Abstract Project 1640 is a suite of instrumentation and software focused on high-contrast imaging of exoplanets, probing the parameter space of companion size > 1MJ and distance 5-50 AU around the host stars. The instrument consists of an apodized Lyot coronagraph, with a Mach-Zender interferometer and an integral field spectrograph, forming data cubes of dimensions… Read more

Power Transformer Monitoring System

Published Jun 15, 2017

Abstract Monitoring and diagnosis of power as well as distribution transformer is the most important process for extending the life of transformer. A transformer monitoring system is already developed by Siemens which is based on SCADA system. But that system can’t be used in small scale industry because most of the industry lacks in automation…. Read more

Anomaly Correction by Optimal Trading Frequency

Published Jun 15, 2017

Abstract Under the assumption that security prices follow random walk, we look at price versus different moving averages. Different periods of moving averages give investor different signals and we assume that a rational investor would want to buy more when the price goes down. This paper provides a theoretical model for an investor to systematically… Read more

Cherenkov Telescope Array Mirror Alignment Report

Published Apr 18, 2015

Abstract Introduction The Cherenkov Telescope Array (CTA) is a groundbased observatory for gamma rays with very high energy characteristics within the range of 10 GeV to 100 TeV. It is currently still under development. As the title of the project suggests, it takes advantage of the Cherenkov radiation that is produced by the gamma ray’s… Read more

Classification of Neocortical Neurons Using Affinity Propagation

Published Apr 18, 2015

Abstract Determining the circuitry of the neocortex requires an understanding of its components, which in turn necessitates a classification scheme of neocortical neurons. The neocortex consists primarily of excitatory pyramidal neurons (~80% of neocortical neurons) and inhibitory interneurons (~20% of neocortical neurons). Neocortical interneurons are ideally positioned to control circuit dynamics. GABAergic interneurons, in particular,… Read more

Creation of Live Lung Slices and Analysis of Cell-Matrix Interactions for Regionalized Human Lung Regeneration

Published Apr 18, 2015

Abstract Currently, the definitive treatment for end-stage organ failure is orthotropic transplantation, or the transplantation of a whole organ from one patient to another. Due to a critical shortage of viable donor organs, however, the number of unwarranted deaths due to chronic lung disease has increased: an estimated 120,000 deaths per year in the United… Read more

The Effect of Fasudil on Glioma Cell Migration

Published Apr 18, 2015

Abstract Gliomas are tumors arising from glial cells that are highly infiltrative within the brain. Their extensive migratory patterns greatly limit the treatment options and prognoses for patients. It has been shown that glioma cells undergo migration in a unique manner that relies heavily on non-muscle myosin II. Since functionality of non-muscle myosin II requires… Read more

Characterizing the Biomechanical and Biochemical Properties of Mouse Uterine Tissue

Published Apr 18, 2015

Abstract For a successful pregnancy, the uterus and the cervix work together as a biomechanical structure to protect the fetus until term. During gestation, typically 37 weeks, the uterus undergoes a growth transformation to accommodate the growing fetus and to prepare for labor. This uterine growth is characterized by an increase of its wet weight,… Read more

GEM Cell Line Establishment, Characterization, and Analysis

Published Apr 18, 2015

Abstract The use of in-vitro cell lines in conjunction with in-vivo mouse models is a common practice in the study of cancer. Culturing cells with the same genotypes as the specific strains of mice being used in studies can be very important and useful in supplementing the research and findings in-vivo. The purpose of this… Read more

The Verification of a Novel Explant System Used to Determine the Role of Osteocytes in the Breast Cancer Vicious Cycle

Published Apr 18, 2015

Abstract Breast cancer affects one in eight women per year, and 70% of patients with stage IV breast cancer develop metastases in bone, causing life-threatening side effects. We examine the use of an explant system to mimic breast cancer metastasis to bone without confounding cell types and to determine the role that osteocytes, the bone… Read more

Identifying Factors that Control Mechanoreceptor Neuron Development in C. elegans

Published Apr 18, 2015

Abstract Mechanosensation, or converting mechanical forces of external touch into electrical signals, is easily studied in Caenorhabditis elegans (C. elegans), a transparent nematode with a well-understood nervous system and a fully sequenced genome. The mechanosensory system mediates growth and development in most organisms; a lack of or defect in mechanosensory stimulation can lead to developmental… Read more

Identification of Inhibitors of Phosphate-activated Glutaminase for the Pharmacotherapy of Schizophrenia

Published Apr 18, 2015

Abstract In the brain, phosphate-activated glutaminase catalyzes the recycling of glutamine back to glutamate for excitatory neurotransmission. In mice, genetic knockdown of phosphate-activated glutaminase has been shown to confer resilience to schizophrenia-like symptoms, suggesting that inhibition of glutaminase may have therapeutic potential for the pharmacotherapy of schizophrenia. As there are no known neuroactive inhibitors of… Read more

Poliovirus Receptor CD155 Over-Expression Effect on Migration in C6 Glioma Cells

Published Apr 18, 2015

Abstract Cell migration plays a key role in brain cancer invasion, an early step in metastasis, and proteins that regulate migration are often up-regulated in tumor cells. The poliovirus receptor CD155 has recently been shown to affect migration levels of select malignant glioma strains, fueling the exploration of treating brain cancer with oncolytic virus recombinants…. Read more

Relationships between Oncologist Gender, Participatory Decision Making, Anxiety and Breast Cancer Care

Published Apr 18, 2015

Abstract The discovery that adjuvant treatment (chemotherapy and radiotherapy) after lumpectomy contributes to high survival rates has been a groundbreaking development in modern breast cancer care. Participatory decision-making (PDM) is a communication style that involves active interactions and discourse between doctors and patients. Although the receipt of adjuvant therapy for various types of cancers has… Read more

Identifying serum-inducible sequence elements on the mouse ZFP36 promoter

Published Apr 18, 2015

Abstract Zinc finger protein 36 (ZFP36) is an RNA-binding protein that downregulates the translation of certain gene products by inducing the degradation of mRNA. ZFP36 is an immediate-early gene: its transcription is activated directly following appropriate cellular stimuli, without any need for intervening protein synthesis. Prominent mRNA targets of ZFP36 are tumor necrosis factor (TNF),… Read more

Lipophilic Tracer DiI Used for Neuronal Tracing in the Fixed Hippocampal Formations of Mice

Published Apr 18, 2015

Abstract Both the hippocampus and the entorhinal cortex are involved in memory formation. It is thought that they work together to create a loop that is involved in the formation of long term memories. The entorhinal cortex sends projections to the CA1 field of the hippocampus and the CA1 field sends projections back to the… Read more

CT Based Semi-Automated Method for Pneumonia Severity in Mice

Published Apr 18, 2015

Abstract Misdiagnosis of community-acquired pneumonia is an important clinical problem, leading to a high rate of mortality. Diagnoses are typically conducted using two-dimensional chest x-rays, which have shown to be time-consuming and inaccurate. In an effort to improve the current diagnostic method, we utilized Micro-Computed Tomography (MicroCT) and image analysis software to develop a diagnostic… Read more