Review ArticlesVolume 12, Spring 2018

Treating Neurodegenerative Disorders: Towards Detailed Pathophysiology and Precision Medicine

Katie Gu

Stanford University

The following paper reviews current literature on disease etiology, pathophysiology, and therapeutic options of neurodegenerative disorder (NDs). We first discuss current directions of disease management and treatment, and highlight technical hindrances of current gene therapy-based treatments as well as significant ethical, regulatory, and efficacy-based concerns present in current stem cell treatment options for Alzheimer’s, Parkinson’s and Huntington’s Disease. We then suggest a narrower focus for future research on identifying molecular, pathological, and biomarker-based disease progression that can in turn inform the development of novel approaches in developing ND therapies.